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Science & DTx

We believe in responsible innovation

We believe that working systematically, learning from data and leveraging the latest technologies will allow us to achieve remarkable things in mental health: eliminating guess work, and expediting recovery.

Mental health is complex... so we bring together the best scientific and clinical minds to learn from the data


At ieso, we aim to make high-quality, evidence-based mental healthcare accessible to all. Around the world, individuals in need often have to wait too long for help, and even when it does come it may be poor quality or not be right for them. While we’ve seen tremendous progress in other areas of healthcare over the past 50 years, mental health has fallen behind. We’re determined to change that.

Just like for physical healthcare, we’ve shown learning from data can transform best practice in care. We’re using the latest scientific methods to help crack the challenge, producing digital products that are derived from scientific data analysis and clinically validated.

ieso Therapy Service captures, with permission, the exchange between a therapist and patient. Coupled with session-by-session progress measures, ieso has a globally unique, de-identified dataset that we analyse to increase the quality and effectiveness of therapy.

Psychological therapy can be highly effective...


But historically it has been impossible to predict which elements of therapy provide specific benefits to patients. The result? A relatively inefficient, one-size-fits-all approach to mental healthcare where only approximately 50% of patients recover.

ieso’s approach allows us to overcome the traditional barrier: how can we possibly improve therapy when past conversations are lost - captured only by imperfect human memory?

We’re focused on three key challenges to deliver safe and effective products that are engaging and trusted:

Start sooner

ieso's Therapy Service allows patients to access treatment faster and makes therapy delivery more efficient (6.1 ieso sessions vs. the average 7.5 sessions). Accessing psychological therapy sooner is associated with better mental health outcomes) and lower healthcare costs.

Improve quality

We have developed AI-based tools to monitor 100% of therapy delivered. By measuring session-by-session patient progress and analysing precise elements of psychological therapy, we are pinpointing the ‘active ingredients’ of therapy to help ensure that each patient receives exactly the right care.

Treat smarter

Often people suffering from very different things are grouped together under a broad diagnosis like “depression”. Our research has uncovered different sub-types of mental health conditions and shown how people with different types follow specific trajectories on their path to recovery. This offers new ways to personalise treatments that provide therapies that are most likely to help everyone.

We work in partnership with like-minded organisations to accelerate progress to better mental health

There’s no time to waste – so we’re working with complementary partners across different sectors to drive new insight into mental health. We’ve partnered with over 15 organisations across Pharma, Tech and Academia, including Roche, the University of Cambridge and Imperial College London.

We share our findings to help advance mental health science

We publish our research findings in peer-reviewed academic journals (e.g., The Lancet; JAMA), as well as through easier to read blogs and newsletters. We want our findings and insights to be shared to help drive progress across the whole field of mental health science research. For updates on when we publish new research papers, blogs and other resources sign up to our newsletter.

The relationship between patient language and outcomes
Ewbank, M. P., Cummins, R., Tablan, V., Catarino, A., Buchholz, S., & Blackwell, A. D.

ieso commissioned this research study, using a deep learning approach, to understand the relationship between patient language and outcomes in internet-enabled cognitive behavioural therapy.

Using tech to associate therapist variables with outcomes
Bateup, S., Palmer, C., & Catarino, A.

ieso uses therapy transcripts derived from internet enabled cognitive behavioural therapy (CBT) treatment sessions to understand how therapist variables are associated with clinical outcomes in IAPT

Depressive states and state transitions in CBT
Catarino, A., Fawcett, J. M., Ewbank, M. P., Bateup, S., Cummins, R., Tablan, V., & Blackwell, A. D.

ieso uses a data-driven approach to define fluid depressive states and explore how patients transition between these states in response to cognitive behavioural therapy (CBT).

TIM: Psychotherapy insights tool
Cummins, R., Ewbank, M. P., Martin, A., Tablan, V., Catarino, A., & Blackwell, A. D.

ieso introduces and demonstrates the usefulness of a tool that automatically annotates therapist utterances in real-time according to the therapeutic role

Associating psychotherapy content and clinical outcomes
Ewbank, M. P., Cummins, R., Tablan, V., Bateup, S., Catarino, A., Martin, A. J., & Blackwell, A. D.

In this study, ieso adopts a deep learning model to automatically categorize therapist utterances from approximately 90 000 hours of internet-enabled cognitive behavior therapy (CBT).

Perceptions of chatbots in therapy
Bell, S., Wood, C., & Sarkar, A.

ieso piloted a comparative study of therapy sessions following the interaction of 10 participants with human therapists versus a chatbot to recommend ways of overcoming the drawbacks of chatbots

Demographic and clinical predictors of outcome
Catarino, A., Bateup, S., Tablan, V., Innes, K., Freer, S., Richards, A., ... & Blackwell, A. D.

This study, commissioned by ieso, investigates the demographic and clinical predictors of response to one-to-one CBT delivered via the internet

RCT: Psychotherapy for depression
Kessler, D., Lewis, G., Kaur, S., Wiles, N., King, M., Weich, S., ... & Peters, T. J.

In this multicentre, randomised controlled trial, ieso investigates the effectiveness of CBT delivered online in real time by a therapist for patients with depression in primary care

Meeting the global mental health challenge through clinical grade digital therapeutics (DTx)

There is a worldwide shortage of therapists, with individuals in some parts of world having no prospect of ever receiving help through therapy. We need to radically scale up care, using automation and augmentation to make scarce clinical resources go further and democratise access to quality mental health care. Born from the de-identified data in our virtual care platform, our clinical experience, and tested in real-world settings, our digital therapeutics will raise the bar for engagement, outcome, and recovery.

Conduct an assessment to understand presenting problems and symptoms
Personalise a program to each patient’s unique needs
Wrap the digital intervention with a patient-centric service delivery and care coordination program
Create a dynamic treatment plan using evidence-based protocols
Provide practical exercises to complete in-app and between sessions

Meeting the global mental health challenge through clinical grade digital therapeutics (DTx)

There is a worldwide shortage of therapists, with individuals in some parts of world having no prospect of ever receiving help through therapy. We need to radically scale-up care, using automation and augmentation to make scarce clinical resources go further and democratize access to quality mental health care. Born from the de-identified data in our virtual care platform, our clinical experience, and tested in real-world settings, our digital therapeutics will raise the bar for engagement, outcome, and recovery.

ieso DTx programs will:

Conduct an assessment to understand presenting problems and symptoms
Personalise a program to each patient’s unique needs
Wrap the digital intervention with a patient-centric service delivery and care coordination program
Create a dynamic treatment plan, using evidence-based protocols
Provide practical exercises to complete in-app and between sessions

Meet the team

Dr Clare Palmer

Director of Evidence Generation

Dr Ana Catarino​

Director of Clinical Science

Dr Louise Marshall

Director of Mental Health Sciences

Dr Ronan Cummins

Director of AI Research

Dr Michael Ewbank

Senior Scientist

Dr Andy Blackwell

Group Chief Science & Strategy Officer

Dr Valentin Tablan

Chief Artificial Intelligence Officer

Dr Andrew Welchman

EVP Impact

Where next?
ieso’s four research streams

We are working on creating breakthroughs in four crucial areas of mental healthcare. 

1. Right treatment first time

Therapy is expensive - and recovery requires the right intervention. How can we avoid the costly revolving door?

2. Active dose of therapy, every time

Therapists vary and clinical quality often depends on therapist intuition and experience. How can we consistently maximise dose and chances of recovery?

3. Accessibility, for everyone everywhere

Treatment is expensive and clinician time is scarce. How can digital treatment reduce the cost and increase the accessibility of care?

4. Prevention is better than cure

Helping patients stay well and detecting problems early saves money and lives. How can data and technology make this a reality?

Science news

Our approach means we’re continually gathering a new understanding of what works in treatment, and why. Read our latest news, research and articles written by people shaping the future of mental healthcare.

Article
4 Min Read
7 Feb 2023

ieso’s Director of Mental Health Research, Dr Louise Marshall, welcomes the launch of Nature Mental Health journal by the Springer Nature Group.

News
3 Min Read
31 Jan 2023

Dave Icke has joined the company as Executive Chair. Dave will lead day-to-day management of the company and chair the Board of Directors.

Article
3 Min Read
15 Dec 2022

In our latest expert article, Daniella Quinn and Dr Michael Ewbank explain how we’ve been analysing the way patients type and what it can tell us about how they engage with digital therapy

News
24 Nov 2022

Watch our Director of Mental Health Sciences Dr Louise Marshall’s presentation at MQ Mental Health Research Mental Health Science Festival 2022

News
3 Min Read
21 Nov 2022

ieso has been selected as the Most Transformative Digital Healthcare Company at the 2022 OBN Awards, held at the Royal Lancaster in London.

News
2 Min Read
16 Nov 2022

ieso’s Chief AI Officer, Dr Valentin Tablan was featured in IEEE Pulse magazine’s recent article on how AI is being used to improve mental health treatment

News
3 Nov 2022

The UK Department of International Trade (DIT) has selected ieso as one of the delegates to exhibit on the UK pavilion at HLTH 2022

ieso selected by UK Department of International Trade to showcase at HLTH 2022
News
1 Min Read
20 Oct 2022

Head of Payer Development at ieso, Deborah Cleary joined the UK Department for International Trade (DIT) last evening for the official launch of the Digital Health Playbook - 2023 Edition.

Blog
5 Min Read
18 Oct 2022

We had a conversation with CBT Therapist Peter O’Brien, one of ieso's affiliate clinicians, who consistently achieves outstanding outcomes in his treatment, about his approach and advice.

News
1 Min Read
3 Oct 2022

ieso’s SVP Clinical Innovation, Jennifer Gentile, featured in MedCity News report on their INVEST Digital Health Conference in Dallas.

News
1 Min Read
30 Sep 2022

ieso’s EVP Impact, Dr Andrew Welchman, recently featured in Behavioral Health Business’s article on his panel at Massachusetts General Hospital Psychiatry Academy Future of Mental Health Conference.

Article
3 Min
15 Sep 2022

In the first of The Team Spotlight series, we speak to Gamze Ekinci Ozkoca about her role as Test Team Lead within Engineering.

News
3 Min Read
12 Sep 2022

ieso shortlisted for celebrated OBN Award for Most Transformative Digital Healthcare Company

Article
2 Min Read
18 Aug 2022

ieso’s Chief Scientific Officer, Dr Andy Blackwell, was featured in Health Tech World’s recently published article, showcasing 10 TED talks that transformed the health tech space.

Article
2 Min Read

Learn directly from the experts in ieso's mental health tech podcast, 'Thinking Ahead'. In case you missed it, here is a recap of the latest episodes.

News
2 Min Read
15 Aug 2022

ieso's Dr Ana Catarino named as one of Business Insider's 30 under 40 in Healthcare for 2022

Article
6 Min read
04 Aug 2022

In our latest article, we look at the results and implications of our latest research study with Shaun Mehew and Jennifer Gentile

News
2 Min Read
02 Aug 2022

ieso’s Group Chief Science and Strategy Officer, Dr Andy Blackwell features in pharmaphorum's article “Beyond the pill in an outcome-based world”

News
2 Min Read
28 Jul 2022

ieso features in Secure Futures magazine for their article "Could AI make mental health therapy more effective"

News
2 Min Read
15 Jul 2022

ieso submits evidence to the UK Department of Health and Social Care to inform the Government’s 10-year Mental Health and Wellbeing Plan

Article
5 Min Read
21 June 2022

Our NHS Market Development Director Rachel Websdale and EVP Clinical Clare Hurley sat down to talk about what the partnership has achieved and where it will go next in our latest blog.

News
1 Min Read
17 Jun 2022

LTC News have published a spotlight article on ieso’s latest study results. This comes a week after the announcement of ieso's research study, conducted with support from Roche Diabetes Care Limited.

News
2 Min Read
13 Jun 2022

Dr Andrew Welchman, Executive Vice President for Impact at ieso, recently appeared on AI for Good’s Health Discovery series to explore how artificial intelligence can improve mental health.

News
8 Min Read
6 Jun 2022

Patients who received ieso online cognitive behavioral therapy tailored for patients with Type 2 diabetes reported improvements in depression and anxiety, which resulted in better diabetes management.

ieso announces results of study on online therapy for diabetes
Article
5 Min Read
31 May 2022

A new era of mental health science: Read part three of our three-part series ‘The Future of Mental Health Care’

News
2 Min Read
27 May 2022

ieso join Self Space, Livi, Bloom and Woebot in the Stylist’s list of the best remote therapy services that are improving access for those seeking mental health support

News
1 Min Read
26 May 2022

Watch our Chief AI Officer Valentin Tablan's presentation at Applied Machine Learning Days 2022 ...

Article
5 Min Read
24 May 2022

Next generation digital therapy: Read part two of our three-part series 'The Future of Mental Health Care'

News
3 Min Read
20 May 2022

ieso is very pleased to announce the appointment of Clare Hurley as EVP Clinical

Article
3 Min Read
17 May 2022

Wake-up and smell the AI: Read part one of our three-part series ‘The Future of Mental Health Care'

News
2 Min Read
13 May 2022

Acknowledging research-driven innovation ensures the continuous improvement of healthcare in the UK and human health globally. Congratulations to this year’s Prix Galien UK winners...

News
2 Min Read
3 May 2022

ieso shortlisted for prestigious Prix Galien UK Best Digital Health Solution award

Blog
3 Min Read
28 Apr 2022

Thomas Insel, former director of the National Institute of Mental Health and author of 'Healing: Our Path from Mental Illness to Mental Health', explains why he is intrigued by what ieso is doing

Article
11 Min Read
01 Apr 2022

Our Director of Clinical Science, Dr Ana Catarino, explains how ieso and The University of Sheffield identified new depression subtypes in our latest expert article

Blog
4 Min Read
30 Mar 2022

From Real-World Data to next Generation Mental Healthcare: in this article, our Chief AI Officer Valentin Tablan summarises his talk at Applied Machine Learning Days 2022 for those who missed it

News
2 Min Read
25 Mar 2022

ieso were delighted to not only be support partners of the HSJ Partnership Awards ceremony but also shortlisted finalists for 'Best Mental Health Partnership with the NHS' with Dorset HealthCare

News
3 Min Read
23 Mar 2022

ieso is delighted to announce the appointment of Dr Louise Marshall as our Director of Mental Health Sciences

Blog
3 Min Read
16 Mar 2022

ieso has joined the Digital Therapeutics Alliance (DTA), a non-profit association of industry leaders with a mission to drive awareness and adoption of digital therapies

Podcast
2 Min Read

Interested in how AI and data are being used today to improve patient outcomes for therapists treating mental health conditions? Tune in to our latest podcast to find out more

News
5 Min Read
18 Feb 2022

Rachel Websdale has this month joined ieso from Push Doctor, where she was their Head of NHS accounts

News
4 Min Read
26 Jan 2022

Meeting regulatory standards is not the only ingredient essential to the responsible innovation of AI-enabled hardware in the healthcare arena, as our Chief AI Officer reflects

Podcast
2 Min Read

Want to know how research into subtypes of depression and their responses to treatment is paving the way for an end to one-size-fits-all treatment for depression? Tune in to our latest podcast

News
2 Min Read
12 Jan 2022

ieso, in partnership with Dorset HealthCare University NHS Foundation Trust, have been shortlisted for “Best Mental Health Partnership with the NHS” at the HSJ Partnership Awards 2022

Podcast
2 Min Read

Did you know that rapport and empathy aren’t key ingredients in effective CBT? Find out more in Does Therapy work? - the second episode of ieso’s mental health-tech podcast, Thinking Ahead

News
4 Min Read
6 Dec 2021

ieso spoke to MIT Technology Review to discuss how using AI to examine the language used by therapists could lead to more people feeling better and staying better

News
5 Min Read
23 Nov 2021

UK innovator closes Series B financing to develop AI-enabled, evidence-based digital therapeutics built on the world's largest mental health treatment data set

News
3 Min Read
22 Nov 2021

ieso's mood and symptom checker asks How Are Things? and creates an evidence-based report from a psychological wellbeing professional to give users a clearer picture of their mental health

Podcast
2 Min Read

Listen in to the first episode of our new mental health tech podcast, Thinking Ahead. Hear from our CEO, Nigel Pitchford, about how we’re scaling and staying true to our social purpose.

News
6 Min Read
4 Nov 2021

ieso reflects on the legacy of Dr Aaron Beck, the highly respected and pioneering neurologist who developed CBT treatment, who died this week at the age of 100

News
1 Min Read
15 Oct 2021

ieso's Chief Science and Strategy Officer Dr Andy Blackwell joins the panel at Uppsala Health Summit to discuss “Innovative Strategies for Closing the Treatment Gap”

Blog
3 Min Read
10 Oct 2021

The theme of this year’s World Mental Health Day (10th October) is ‘Mental health in an unequal world’

News
2 Min Read
5 Oct 2021

Our ambition is to not only provide world-class therapy, it’s to transform mental healthcare around the world

News
2 Min Read
2 Oct 2021

ieso, a leading provider of evidence-based, online cognitive behavioural therapy (CBT) and innovator of ground-breaking research, features in The Economist’s latest review of mental healthcare program

News
3 Min Read
13 Sep 2021

Jeremy Cripps, a Chartered Psychologist and UK Clinical Lead at ieso, shares his lived experience of mental health. In an interview with Ian Florence, he delves deeper into his self-disclosure

News
3 Min Read
9 Sept 2021

Dr Andrew Welchman joins ieso today as our first Executive Vice President for Impact.

News
2 Min Read
11 Aug 2021

ieso featured in Sifted’s review of mental health start-ups across Europe who are addressing the extra strain on people’s mental health caused by the pandemic

News
4 Min Read
29 Jun 2021

ieso announced June 29 that is has been granted a new patent by the US Patent and Trademark Office (USPTO).

ieso granted U.S. patent for use of AI and tech to improve mental health provision
News
1 Min Read
28 May 2021

Read the full profile of 22 UK up-and-coming mental health and wellbeing start-ups...

ieso placed No.1 in top 22 mental healthcare companies in the UK
News
3 Min Read
19 May 2021

Five subtypes of depression have been identified in new research from the University of Sheffield and ieso.

Study shows depression subtypes linked to varying recovery rates
News
2 Min Read
11 May 2021

Marie Claire have published a complete guide to online therapy: what it is, its benefits and some resources to help people get started on learning to challenge thoughts that may be causing distress

Podcast
20 Min Listen
11 May 2021

As part of Mental Health Awareness Week, ieso Chief Science and Strategy Officer Dr Andy Blackwell features on Tech Talks podcast, a show offering insight into the tech sector.

News
1 Min Read
10 May 2021

ieso, a leader in evidence-based cognitive behavioural therapy provisions and innovator of ground breaking research, is recognised in the Evening Standard's best therapy tools

Article
3 Min Read
20 Apr 2021

Now, more than ever, technology and data science have an important and exciting role to play in helping people to live lives unhindered by mental health issues.

ieso is transforming mental health, transforming how it’s treated.
News
3 Min Read
22 Mar 2021

ieso's new study has analysed the largest available set of digital mental health conversations in relation to Covid-19 over the past 12 months.

Largest ever analysis of digital mental health conversations
News
3 Min Read
12 Feb 2021

Read what health care professionals and patient advocates think of How Are Things?, and where they see it fitting in the patient journey...

News
3 Min Read
11 Feb 2021

Digital providers and experts from over 20 countries have gathered a staggering number of insights about mental health during the pandemic from potentially upwards of 50 million users worldwide.

Digital providers unite to support global mental health during COVID-19 pandemic
News
3 Min Read
28 Jan 2021

ieso responded to the House of Lords Covid-19 Committee’s call for evidence into the impact of digitalisation on the four key drivers of wellbeing

ieso contributes to the House of Lords COVID-19 Committee's inquiry
News
2 Min Read
13 Jan 2021

ieso has created safe, patient-centred technology that meets McKinsey's six interconnected building blocks to establish a scalable business in digital health

Research Paper
15 Min Read
2021

ieso commissioned this research study, using a deep learning approach, to understand the relationship between patient language and outcomes in internet-enabled cognitive behavioural therapy.

The relationship between patient language and outcomes
News
2 Min Read
20 Dec 2020

ieso, a leader in internet-enabled cognitive behavioural therapy, is pleased to announce we have been named as one of the top 19 mental health start-ups in Europe

News
3 Min Read
9 Dec 2020

The much anticipated second wave of coronavirus cases was thought to bring with it a rise in mental health difficulties.

News
4 Min Read
24 Nov 2020

ieso are pleased to announce the appointment of Stephen Freer as Chief Clinical Officer.

News
3 Min Read
18 Nov 2020

ieso, a leader in evidence-based cognitive behavioural therapy provisions and ground breaking research, is excited to announce we are a winner in Red Herring's Top 100 North America

News
3 Min Read
24 May 2020

With this year’s #IWD theme being ‘an equal world is an enabled world’ - #eachforequal – ieso advocate equality and enablement for everyone.

ieso supports Microsoft Data Science programme
Blog
4 Min Read
22 May 2020

In the fourth blog post of this series, Sarah Bateup provides advice around the common phenomena when moving to non-face to face therapy delivery and more...

Blog
6 Min Read
21 May 2020

In the third blog post of this series, Sarah Bateup provides advice around how to deal with patient contact in-between therapy delivery and more...

Blog
5 Min Read
21 May 2020

In the second blog post of this series, Sarah Bateup provides advice around housekeeping and consent when moving to digital therapy methods and more...

Blog
7 Min Read
21 May 2020

In the first blog post of this series, Sarah Bateup provides advice around the best preparation for seeing patients using digital therapy methods during COVID-19 and more...

News
4 Min Read
01 May 2020

ieso, the leader in online cognitive behavioural therapy provision and an innovator in mental healthcare, is excited to announce that it has been named a winner in Red Herring’s Top 100 Europe.

Research Paper
15 Min Read
2020

ieso uses therapy transcripts derived from internet enabled cognitive behavioural therapy (CBT) treatment sessions to understand how therapist variables are associated with clinical outcomes in IAPT

Using tech to associate therapist variables with outcomes
Research Paper
15 Min Read
2020

ieso uses a data-driven approach to define fluid depressive states and explore how patients transition between these states in response to cognitive behavioural therapy (CBT).

Depressive states and state transitions in CBT
Research Paper
15 Min Read
2019

ieso introduces and demonstrates the usefulness of a tool that automatically annotates therapist utterances in real-time according to the therapeutic role

TIM: Psychotherapy insights tool
Research Paper
15 Min Read
2019

In this study, ieso adopts a deep learning model to automatically categorize therapist utterances from approximately 90 000 hours of internet-enabled cognitive behavior therapy (CBT).

Associating psychotherapy content and clinical outcomes
Research Paper
15 Min Read
2019

ieso piloted a comparative study of therapy sessions following the interaction of 10 participants with human therapists versus a chatbot to recommend ways of overcoming the drawbacks of chatbots

Perceptions of chatbots in therapy
Research Paper
15 Min Read
2018

This study, commissioned by ieso, investigates the demographic and clinical predictors of response to one-to-one CBT delivered via the internet

Demographic and clinical predictors of outcome
Research Paper
15 Min Read
2009

In this multicentre, randomised controlled trial, ieso investigates the effectiveness of CBT delivered online in real time by a therapist for patients with depression in primary care

RCT: Psychotherapy for depression

Join us on our journey to improve mental health access for all

We are now accepting a select number of customers to partner on our journey to scale clinically effective tools to support access to mental healthcare.

ieso raises $53m to address global mental health crisis with digital therapeutics

UK innovator closes Series B financing to develop AI-enabled, evidence-based digital therapeutics built on the world's largest mental health treatment data set.

Read the full article here