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Science & DTx

Using science and digital therapeutics to tackle mental health challenges

ieso is the first company in the world to explore therapy language through machine learning. We work to translate this into digital therapeutics that make precision treatment and assessment accessible anywhere.


Read our research papers

Changing the future of mental health by unlocking the power of clinical data


Our mission is to transform global mental health by unlocking the power of clinical data. We’re revolutionising the way the world understands and treats mental health. We aim to make mental healthcare accessible to all by creating digital assessment and therapeutic tools for mental health conditions.

Just like physical healthcare, insights into mental health can be drawn from big data. At ieso we’re changing the future of mental health by unlocking the power of clinical data.


The ieso team at TEDx

Dr Andy Blackwell is the Group Chief Science and Strategy Officer at ieso. Watch Andy’s talk at TEDxNatick on “Artificial Intelligence Meets Mental Health Therapy” in which he shares our vision for mental health transformation and how we are using AI to improve recovery results for tens of thousands of patients.

Innovation is at the heart of ieso. Our science & DTx research focuses on three themes:

Treat smarter

A one-size-fits-all approach is not effective in meeting individual needs. We need tailored care to drive up recovery rates and reduce relapse.

Scale up

There are not enough therapists in the world to meet care needs. We need to radically scale-up care - using automation and augmentation to make clinical resources go much further - and making care affordable around the globe.

Start sooner

Current interventions are delivered too late. We need to predict and, where possible, prevent mental ill-health to result in better outcomes.

We are on an innovation journey and partner with like-minded organisations that want to improve mental health

We’ve partnered with over 15 organisations including Roche, the University of Cambridge and Imperial College London.

Meet the experts

Dr Louise Marshall

Director of Mental Health Sciences

Dr Ana Catarino​

Director of Clinical Science

Dr Ronan Cummins

Director of AI Research

Dr Michael Ewbank

Senior Scientist

Dr Andy Blackwell

Group Chief Science & Strategy Officer

Dr Valentin Tablan

Chief Artificial Intelligence Officer

Dr Andrew Welchman

EVP for Impact

Hear from the team

"A trusted NHS partner for over a decade, we have delivered over 555,000 hours of transformative CBT typed therapy to over 100,000 people. Combining clinical expertise with our technologically advanced tools, ieso’s mental health solutions allow staff to take a positive step towards mental wellness, and in times of trouble we help employees to find and access the right care for them."
Stephen Freer, EVP Clinical, ieso

Where next?
ieso’s four research streams

We are working on creating breakthroughs in four crucial areas of mental healthcare. 

1. Right treatment first time

Therapy is expensive - and recovery requires the right intervention. How can we avoid the costly revolving door?

2. Active dose of therapy, every time

Therapists vary and clinical quality often depends on therapist intuition and experience. How can we consistently maximise dose and chances of recovery?

3. Accessibility, for everyone everywhere

Treatment is expensive and clinician time is scarce. How can digital treatment reduce the cost and increase the accessibility of care?

4. Prevention is better than cure

Helping patients stay well and detecting problems early saves money and lives. How can data and technology make this a reality?

Our research is published in peer-reviewed journals, including The Lancet and JAMA. Take a read through our papers below:

ieso’s research has been published in key journals over the last ten years, adding crucial knowledge to our understanding of effective mental healthcare. For updates on when we publish new research papers, blogs and other resources sign up to our newsletter.

The relationship between patient language and outcomes
Ewbank, M. P., Cummins, R., Tablan, V., Catarino, A., Buchholz, S., & Blackwell, A. D.

ieso commissioned this research study, using a deep learning approach, to understand the relationship between patient language and outcomes in internet-enabled cognitive behavioural therapy.

Using tech to associate therapist variables with outcomes
Bateup, S., Palmer, C., & Catarino, A.

ieso uses therapy transcripts derived from internet enabled cognitive behavioural therapy (CBT) treatment sessions to understand how therapist variables are associated with clinical outcomes in IAPT

Depressive states and state transitions in CBT
Catarino, A., Fawcett, J. M., Ewbank, M. P., Bateup, S., Cummins, R., Tablan, V., & Blackwell, A. D.

ieso uses a data-driven approach to define fluid depressive states and explore how patients transition between these states in response to cognitive behavioural therapy (CBT).

TIM: Psychotherapy insights tool
Cummins, R., Ewbank, M. P., Martin, A., Tablan, V., Catarino, A., & Blackwell, A. D.

ieso introduces and demonstrates the usefulness of a tool that automatically annotates therapist utterances in real-time according to the therapeutic role

Associating psychotherapy content and clinical outcomes
Ewbank, M. P., Cummins, R., Tablan, V., Bateup, S., Catarino, A., Martin, A. J., & Blackwell, A. D.

In this study, ieso adopts a deep learning model to automatically categorize therapist utterances from approximately 90 000 hours of internet-enabled cognitive behavior therapy (CBT).

Perceptions of chatbots in therapy
Bell, S., Wood, C., & Sarkar, A.

ieso piloted a comparative study of therapy sessions following the interaction of 10 participants with human therapists versus a chatbot to recommend ways of overcoming the drawbacks of chatbots

Demographic and clinical predictors of outcome
Catarino, A., Bateup, S., Tablan, V., Innes, K., Freer, S., Richards, A., ... & Blackwell, A. D.

This study, commissioned by ieso, investigates the demographic and clinical predictors of response to one-to-one CBT delivered via the internet

RCT: Psychotherapy for depression
Kessler, D., Lewis, G., Kaur, S., Wiles, N., King, M., Weich, S., ... & Peters, T. J.

In this multicentre, randomised controlled trial, ieso investigates the effectiveness of CBT delivered online in real time by a therapist for patients with depression in primary care

Science news

Our approach means we’re continually gathering a new understanding of what works in treatment, and why. Read our latest news, research and articles written by people shaping the future of mental healthcare.

Article
2 Min Read
18 Aug 2022

ieso’s Chief Scientific Officer, Dr Andy Blackwell, was featured in Health Tech World’s recently published article, showcasing 10 TED talks that transformed the health tech space.

News
2 Min Read
15 Aug 2022

ieso's Dr Ana Catarino named as one of Business Insider's 30 under 40 in Healthcare for 2022

Article
6 Min read
04 Aug 2022

In our latest article, we look at the results and implications of our latest research study with Shaun Mehew and Jennifer Gentile

News
2 Min Read
02 Aug 2022

ieso’s Group Chief Science and Strategy Officer, Dr Andy Blackwell features in pharmaphorum's article “Beyond the pill in an outcome-based world”

News
2 Min Read
28 Jul 2022

ieso features in Secure Futures magazine for their article "Could AI make mental health therapy more effective"

News
2 Min Read
15 Jul 2022

ieso submits evidence to the UK Department of Health and Social Care to inform the Government’s 10-year Mental Health and Wellbeing Plan

Article
5 Min Read
31 May 2022

A new era of mental health science: Read part three of our three-part series ‘The Future of Mental Health Care’

News
1 Min Read
26 May 2022

Watch our Chief AI Officer Valentin Tablan's presentation at Applied Machine Learning Days 2022 ...

Article
3 Min Read
17 May 2022

Wake-up and smell the AI: Read part one of our three-part series ‘The Future of Mental Health Care'

Blog
3 Min Read
28 Apr 2022

Thomas Insel, former director of the National Institute of Mental Health and author of 'Healing: Our Path from Mental Illness to Mental Health', explains why he is intrigued by what ieso is doing

Article
11 Min Read
01 Apr 2022

Our Director of Clinical Science, Dr Ana Catarino, explains how ieso and The University of Sheffield identified new depression subtypes in our latest expert article

Blog
4 Min Read
30 Mar 2022

From Real-World Data to next Generation Mental Healthcare: in this article, our Chief AI Officer Valentin Tablan summarises his talk at Applied Machine Learning Days 2022 for those who missed it

News
2 Min Read
25 Mar 2022

ieso were delighted to not only be support partners of the HSJ Partnership Awards ceremony but also shortlisted finalists for 'Best Mental Health Partnership with the NHS' with Dorset HealthCare

News
3 Min Read
23 Mar 2022

ieso is delighted to announce the appointment of Dr Louise Marshall as our Director of Mental Health Sciences

Blog
3 Min Read
16 Mar 2022

ieso has joined the Digital Therapeutics Alliance (DTA), a non-profit association of industry leaders with a mission to drive awareness and adoption of digital therapies

Podcast
2 Min Read
9 Mar 2022

Interested in how AI and data are being used today to improve patient outcomes for therapists treating mental health conditions? Tune in to our latest podcast to find out more

News
4 Min Read
26 Jan 2022

Meeting regulatory standards is not the only ingredient essential to the responsible innovation of AI-enabled hardware in the healthcare arena, as our Chief AI Officer reflects

Podcast
2 Min Read
19 Jan 2022

Want to know how research into subtypes of depression and their responses to treatment is paving the way for an end to one-size-fits-all treatment for depression? Tune in to our latest podcast

News
2 Min Read
12 Jan 2022

ieso, in partnership with Dorset HealthCare University NHS Foundation Trust, have been shortlisted for “Best Mental Health Partnership with the NHS” at the HSJ Partnership Awards 2022

Podcast
2 Min Read
14 Dec 2021

Did you know that rapport and empathy aren’t key ingredients in effective CBT? Find out more in Does Therapy work? - the second episode of ieso’s mental health-tech podcast, Thinking Ahead

News
4 Min Read
6 Dec 2021

ieso spoke to MIT Technology Review to discuss how using AI to examine the language used by therapists could lead to more people feeling better and staying better

News
5 Min Read
23 Nov 2021

UK innovator closes Series B financing to develop AI-enabled, evidence-based digital therapeutics built on the world's largest mental health treatment data set

News
3 Min Read
22 Nov 2021

ieso's mood and symptom checker asks How Are Things? and creates an evidence-based report from a psychological wellbeing professional to give users a clearer picture of their mental health

Podcast
2 Min Read
17 Nov 2021

Listen in to the first episode of our new mental health tech podcast, Thinking Ahead. Hear from our CEO, Nigel Pitchford, about how we’re scaling and staying true to our social purpose.

News
6 Min Read
4 Nov 2021

ieso reflects on the legacy of Dr Aaron Beck, the highly respected and pioneering neurologist who developed CBT treatment, who died this week at the age of 100

News
1 Min Read
15 Oct 2021

ieso's Chief Science and Strategy Officer Dr Andy Blackwell joins the panel at Uppsala Health Summit to discuss “Innovative Strategies for Closing the Treatment Gap”

Blog
3 Min Read
10 Oct 2021

The theme of this year’s World Mental Health Day (10th October) is ‘Mental health in an unequal world’

News
2 Min Read
5 Oct 2021

Our ambition is to not only provide world-class therapy, it’s to transform mental healthcare around the world

News
2 Min Read
2 Oct 2021

ieso, a leading provider of evidence-based, online cognitive behavioural therapy (CBT) and innovator of ground-breaking research, features in The Economist’s latest review of mental healthcare program

News
4 Min Read
29 Jun 2021

ieso announced June 29 that is has been granted a new patent by the US Patent and Trademark Office (USPTO).

ieso granted U.S. patent for use of AI and tech to improve mental health provision
Podcast
20 Min Listen
11 May 2021

As part of Mental Health Awareness Week, ieso Chief Science and Strategy Officer Dr Andy Blackwell features on Tech Talks podcast, a show offering insight into the tech sector.

News
3 Min Read
12 Feb 2021

Read what health care professionals and patient advocates think of How Are Things?, and where they see it fitting in the patient journey...

News
3 Min Read
24 May 2020

With this year’s #IWD theme being ‘an equal world is an enabled world’ - #eachforequal – ieso advocate equality and enablement for everyone.

ieso supports Microsoft Data Science programme

Find out more

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ieso raises $53m to address global mental health crisis with digital therapeutics

UK innovator closes Series B financing to develop AI-enabled, evidence-based digital therapeutics built on the world's largest mental health treatment data set.

Read the full article here